Great Britain established diplomatic relations with former-colony United States in 1791. In 1893, the British diplomatic mission in Washington was raised from a Legation to an Embassy. All italicised names indicate Envoys Extraordinary, while plain text indicates Ambassadors Extraordinary.

*Bios of Ambassadors are from external website Wikipedia. The views expressed by Wikipedia are not endorsed nor do they reflect those of Her Majesty's Government.

1. 1791–1795: George Hammond
2. 1796–1800: Robert Liston
3. 1803–1806: Anthony Merry
4. 1806–1809: Hon. David Erskine
5. 1809–1811: Francis Jackson
6. 1811–1812: Augustus Foster
1812–1815: No representation due to the War of 1812
7. 1815–1820: Hon. Charles Bagot
8. 1820–1824: Stratford Canning
9. 1825–1835: Charles Vaughan
10. 1835–1843: Henry Fox
11. 1843–1847: Richard Pakenham
12. 1849–1852: Sir Henry Bulwer
13. 1852–1856: John Crampton
14. 1857–1858: Francis Napier, 10th Lord Napier
15. 1858–1865: Richard Lyons, 2nd Baron Lyons
16. 1865–1867: Sir Frederick Bruce
17. 1867–1881: Sir Edward Thornton
18. 1881–1888: Hon. Lionel Sackville-West
19. 1889–1893: Sir Julian Pauncefote
1893–1902: Sir Julian Pauncefote, Lord Pauncefote from 1899
20. 1902–1903: Sir Michael Herbert
21. 1903–1906: Sir Mortimer Durand
22. 1907–1913: James Bryce
23. 1913–1918: Sir Cecil Spring-Rice
24. 1918–1919: Rufus Isaacs, 1st Earl of Reading
25. 1920–1924: Sir Auckland Geddes
26. 1924–1930: Sir Esme Howard
27. 1930–1939: Sir Ronald Lindsay
28. 1939–1940: Philip Kerr, 11th Marquess of Lothian
29. 1941–1946: Edward Wood, 3rd Viscount Halifax
30. 1946–1948: Archibald Clark Kerr, 1st Baron Inverchapel
31. 1948–1952: Sir Oliver Franks
32. 1952–1956: Sir Roger Makins
33. 1956–1961: Sir Harold Caccia
34. 1961–1965: Sir David Ormsby-Gore
35. 1965–1969: Sir Patrick Dean
36. 1969–1971: John Freeman
37. 1971–1974: Rowland Baring, 3rd Earl of Cromer
38. 1974–1977: Sir Peter Ramsbotham
39. 1977–1979: Peter Jay
40. 1979–1982: Sir Nicholas Henderson
41. 1982–1986: Sir Oliver Wright
42. 1986–1991: Sir Antony Acland
43. 1991–1995: Sir Robin Renwick
44. 1995–1997: Sir John Kerr
45. 1997–2003: Sir Christopher Meyer
46. 2003–2007: Sir David Manning
47. 2007–present: Sir Nigel Sheinwald